ISARIC Global Support Centre (GSC) updates members on the outbreak in Wuhan and highlights its work with member networks and WHO. Encourages the use of standardised data collection.

ISARIC members’ Randomised Control Trial of Lopinavir–Ritonavir in China enrols first patient.

Launch of the ISARIC COVID-19 standardised, open access research resources and clinical data platform. Available online for global use.

ISARIC members in China use ISARIC/WHO Case Report Forms to collect data and publish the first clinical description.

ISARIC’s COVID-19 clinical research resources downloaded by sites across 26 countries.

ISARIC reaffirms its commitment to the principles set out in the 2016 Statement on data sharing in public health emergencies.

ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections (CCP-UK), developed by ISARIC members, opens to enrolment in hospitals in the UK.

Launch of the COVID-19 Clinical Characterisation Protocol Global (CCP Global), a flexible and adaptable research protocol.

ISARIC members’ Randomised Control Trial of Remdesivir in China enrols first patient.

First patient data entered on the ISARIC COVID-19 clinical data platform using ISARIC/WHO Case Report Form.

ISARIC COVID-19 clinical data platform passes the 1,000 patient records mark.

ISARIC members in China publish the first trial results on Lopinavir–Ritonavir.

ISARIC launches the RAPID Case Report Form, with fewer variables, for use in resources-limited settings.

First ISARIC COVID-19 clinical data platform report published with clinical data on >2K patients.

ISARIC members in China use the ISARIC/WHO Case Report Forms to collect data and publish the first study identifying risk factors associated with death.

ISARIC’s COVID-19 clinical research resources downloaded by sites across 186 countries.

ISARIC COVID-19 clinical data platform passes the 10,000 patient records mark.

ISARIC members publish the first trial results for Remdesivir.

ISARIC launches a set of tools to guide researcher to operationalise the Clinical Characterisation Protocol Global (CCP Global).

ISARIC4C investigators publish study characterising clinical features of patients admitted to hospital with COVID-19 during the growth phase of the first wave.

ISARIC clinical research group publishes an article on the importance of global collaboration and harmonised clinical characterisation in COVID-19.

ISARIC member network ALERRT adapts the ISARIC CCP to the African context and launches guidance and documents for operationalising the ALERRT COVID-19 CCP.

ISARIC COVID-19 clinical data platform passes the 50,000 patient records mark.

ISARIC4C investigators publish a study on the ethnicity and outcomes among hospitalised patients with COVID-19.

ISARIC publishes a systematic review of the challenges of clinical research during a pandemic and presents potential solutions.

ISARIC Global Follow-up Protocol registered on the Open Science Framework (OSF), when evidence of prolonged recovery and Long COVID symptoms started emerging from patient groups.

ISARIC4C investigators publish the study on the clinical characterisation of children hospitalised with COVID-19.

ISARIC4C investigators publish the study on the development and validation of a risk score to predict mortality in patients admitted to hospital with COVID-19.

ISARIC Global COVID-19 Paediatric Follow-up working group launched, aiming to assess Long COVID in children.

ISARIC launches the Global Long COVID study aiming to study the long term effects of COVID-19.

ISARIC COVID-19 clinical data platform passes the 100,000 patient records mark.

ISARIC member co-authors a study identifying genetic mechanisms of critical illness in COVID-19.

ISARIC hosts its first virtual evidence forum: How India is identifying best practice in the use of corticosteroids in COVID-19.

ISARIC and GloPID-R co-host the Long-COVID forum, bringing together clinical researchers, healthcare professionals and people living with Long-COVID to identify research gaps.

ISARIC hosts its second virtual evidence forum: Non-Invasive ventilation strategies in COVID-19.

>20,000 downloads of ISARIC COVID-19 resources and >105,000 unique visits, from 210 countries, to ISARIC’s website in 2020.

ISARIC member publishes the results of the study of 6-month consequences of COVID-19 in patients discharged from hospital.

ISARIC4C investigators publish the study of the development and validation of the Deterioration model for adults hospitalised with COVID-19.

ISARIC member publishes a study characterising the first 250,000 COVID-19 hospital admissions in Brazil.

ISARIC COVID-19 clinical data platform passes the 300,000 patient records mark.

ISARIC4C investigators publish study identifying key inflammatory markers for severe COVID-19.

ISARIC hosts its third virtual evidence forum: Use of convalescent plasma in patients hospitalized with COVID-19.

ISARIC COVID-19 clinical data platform passes the half million patient records mark.

ISARIC launches the COVID-19 clinical data dashboard.

ISARIC member publishes a living systematic review aiming to characterise Long COVID.

The ISARIC Clinical Characterisation Group publishes an article on the value of research preparedness and global collaboration for an effective pandemic research response.