Dengue
Dengue is a major, widespread, and growing health problem.
About half of the world’s population live in dengue-endemic areas; each year 100 million people get ill and 40,000 die. Consequently, the World Health Organization identifies dengue as one the world’s top ten threats to human health.
Despite the public health importance of dengue, there has been limited investment into research to develop treatments and understand clinical epidemiology. Clinicians and academics across the ISARIC network have identified this as a research priority. We are collaborating internationally to develop methods that improve the efficiency and quality of clinical research, then implementing these methods in new studies to identify effective treatments and answer the questions that make a difference to patient outcomes.
Characterising Disease
Dengue Clinical Characterisation Protocol
A standardised observational framework to characterise dengue clinical epidemiology and address critical knowledge gaps to improve patient outcomes
Developing methodologies
Core Outcome Set Methods
The Den-core project is an international consensus study to develop a standardised set of outcomes – a ‘core outcome set’ (COS) – to be used by all future dengue treatment trials
Removing barriers
Core Outcome Set Community Involvement
We are engaging with patient representatives, health professionals, psychologists, researchers, methodologists, epidemiologists, journal editors, industry, policy makers, and regulators to develop a Core Outcome Set (COS)| for dengue research. Patient representatives from around the world will be involved in designing and implementing DEN-CORE. By engaging with patient representatives, outcomes that are a priority for patients will also be highlighted in this work.
Publications
News
Delphi survey launched by the ISARIC Dengue Core Outcome Set team
20 July 2024: The Dengue Core Outcome Set (DEN-CORE) team has officially launched the first round of their Delphi survey, focusing on outcomes for hospitalised patients with dengue. Individuals involved with dengue in any way are invited to participate in the definition of the most critical dengue outcomes by emailing dencore@isaric.org with an expression of interest. The survey is available in 11 languages: English, Bahasa, Hindi, Malay, Nepali, Portuguese, Spanish, Sinhala, Tagalog, Thai,
Activities
ISARIC-WHO Webinar: Dengue Core Outcome Sets
ISARIC and WHO will be collaborating to organise a webinar to discuss the dengue core outcome set project (den-core) in the context of dengue clinical trials. When: 22 April from 13:00 to 14:35 (UTC+1) Registration: Visit this link to register for the event by 20 April Programme: Den-Core Webinar Programme Learn more about the den-core project here.