Dengue is a major, widespread, and growing health problem. About half of the world’s population live in dengue-endemic areas; each year 100 million people get ill and 40,000 die. Consequently, the World Health Organization identifies dengue as one the world’s top ten threats to human health.
Despite the public health importance of dengue, there has been limited investments into research to develop treatments and understand clinical epidemiology. Clinicians and academics across the ISARIC network have identified this as a research priority. We are responding through global collaboration to develop methods that improve the efficiency and quality of clinical research, then implementing these methods in new studies to identify effective treatments and answer the questions that make a difference to patient outcomes.