Dengue Core Outcome Set

The Den-core project is an international consensus study to develop a standardised set of outcomes – a ‘core outcome set’ (COS) – to be used by all future dengue treatment trials.
ISARIC Core Outcome Sets
There is currently no effective treatment for dengue and severe dengue that cause significant morbidity and mortality worldwide. We are working with partners to plan new clinical trials that address this pressing issue

To date, dengue research has been based on heterogeneous outcomes measures which have prevented the comparison of results across different studies and limited the impact of the evidence generated.

By incorporating input from a broad range of stakeholders, including patient groups, health professionals and researchers, a core outcome set will ensure that research is both relevant and patient-centred, resulting in better informed clinical and policy decisions on a global scale. The core outcome set will also anchor the development of target product profiles for new therapeutic agents to treat Dengue.

Latest Updates
Project updates coming soon

About the Project

The Den-core team was formed in 2023 to develop a Core Outcome Set (COS) for use in dengue research with input from patient representatives, health professionals, psychologists, researchers, methodologists, epidemiologists, journal editors, industry, policy makers, and regulators.

 

Together, this range of stakeholders will develop a consistent framework for outcome selection and reporting. The COS will contribute to improved research quality, data comparability, and evidence synthesis, ultimately facilitating the development of effective interventions and evidence-based clinical practice.

Key Objectives

 

Defining the scope and applicability of Core Outcome Sets for dengue

Creating Core Outcome Sets and measurement tools to improve dengue research

 Achieving consensus on terminology and definitions for measurement instruments related to dengue Core Outcomes

What is a Core Outcome Set?
A core outcome set provides a minimal list of outcome measures to be reported in all clinical trials in a specific disease area. 

The core outcome set does not preclude trialists from selecting primary, secondary, or safety outcome measures that are not in the core set. 

Having a standardised minimal set of measurements for all clinical trials will ensure patient and clinical relevance, and enables comparability across trials thus facilitating Meta-analysis.

This video developed by Core Outcome Measures in Effectiveness Trials (COMET) initiative explains what core outcome sets are, why they are important, and how patients and the public are involved in developing COS:

 

Participants

Types of Den-core project participants:

  People with lived experience of dengue

Family members/caregivers of people with dengue

Healthcare professionals delivering care to patients with dengue 

Researchers involved in studies of dengue

Other stakeholders who impact dengue treatment (policymakers, regulators, etc.)

 

Our Team

Sophie Yacoub

Sophie Yacoub

Leadership

Daniel Munblit

Daniel Munblit

Leadership

Laura Merson

Laura Merson

Leadership

Xin Hui Chan

Xin Hui Chan

Leadership
Anastasiia Demidova

Anastasiia Demidova

Leadership

Anna-Aigun Mursalova

Anna-Aigun Mursalova

Research

Steering Committee

Lucy Lum

Lucy Lum

Steering Committee
Neelika Malavige

Neelika Malavige

Steering Committee
Bharath Kumar

Bharath Kumar

Steering Committee
Thomas Jäenisch

Thomas Jäenisch

Steering Committee
Patrícia Brasil

Patrícia Brasil

Steering Committee

In collaboration with

Questions?

If you have questions or would like further information, please contact dencore@isaric.org