Dengue Core Outcome Set
To date, dengue research has been based on heterogeneous outcomes measures which have prevented the comparison of results across different studies and limited the impact of the evidence generated.
By incorporating input from a broad range of stakeholders, including patient groups, health professionals and researchers, a core outcome set will ensure that research is both relevant and patient-centred, resulting in better informed clinical and policy decisions on a global scale. The core outcome set will also anchor the development of target product profiles for new therapeutic agents to treat Dengue.
About the Project
The Den-core team was formed in 2023 to develop a Core Outcome Set (COS) for use in dengue research with input from patient representatives, health professionals, psychologists, researchers, methodologists, epidemiologists, journal editors, industry, policy makers, and regulators.
Together, this range of stakeholders will develop a consistent framework for outcome selection and reporting. The COS will contribute to improved research quality, data comparability, and evidence synthesis, ultimately facilitating the development of effective interventions and evidence-based clinical practice.
Defining the scope and applicability of Core Outcome Sets for dengue
Creating Core Outcome Sets and measurement tools to improve dengue research
Achieving consensus on terminology and definitions for measurement instruments related to dengue Core Outcomes
What is a Core Outcome Set?
The core outcome set does not preclude trialists from selecting primary, secondary, or safety outcome measures that are not in the core set.
Having a standardised minimal set of measurements for all clinical trials will ensure patient and clinical relevance, and enables comparability across trials thus facilitating Meta-analysis.
This video developed by Core Outcome Measures in Effectiveness Trials (COMET) initiative explains what core outcome sets are, why they are important, and how patients and the public are involved in developing COS:
Types of Den-core project participants:
People with lived experience of dengue
Family members/caregivers of people with dengue
Healthcare professionals delivering care to patients with dengue
Researchers involved in studies of dengue
Other stakeholders who impact dengue treatment (policymakers, regulators, etc.)
Xin Hui Chan