In collaboration with clinicians and researchers from Asia and South America, ISARIC has launched the Clinical Characterisation Protocol for Dengue (CCP-Dengue).
Dengue, a vector-borne, neglected tropical disease, is associated with substantial morbidity and mortality. The WHO estimates that 390 million dengue infections occur annually. 70% of this burden is in Asia. Recently, there have been massive dengue outbreaks around the world, with tragically high numbers of deaths in Bangladesh and Brazil. Dengue cases are also increasingly being reported from Western Europe and Southern USA, regions that have historically never reported dengue.
Despite this burden, standardised information on the recent clinical epidemiology of patients hospitalised with dengue is lacking. The range of presentations, severity, biochemical and haematological abnormalities, viral serotypes, treatments and clinical outcomes remain poorly characterised and have not been compared across the many regions where dengue presents.
To address this key gap, ISARIC partners are launching the CCP with a focus on Dengue. Led by researchers in India, Vietnam, Pakistan, Nepal, Sri Lanka, Bangladesh and Brazil, ISARIC’s standard protocol and case report forms (CRF) have been tailored to deliver evidence to inform treatment decisions and new clinical trials. The key objectives of this CCP implementation are to understand the patterns of clinical presentation, severity, treatment, and clinical outcomes in hospitalised dengue patients. The evidence generated will additionally help clinicians and health authorities understand patient and treatment-related predictors of hospital mortality. Researchers interested in addressing questions about early dengue are invited to collaborate and lead this science.
In keeping with the collaborative approach of the CCP (including CCP-COVID-19), the CCP-Dengue tools and invitation to participate are open to all clinicians and researchers across the world. Sites can choose the volume of data they collect based on the local resources and research priorities. ISARIC can provide support for data management, statistical analysis, and access to data for collaborative analyses with participating sites.
If you have worked on the CCP previously, you’ll know that ISARIC’s collaborative approach promotes research leadership and recognition among those who collect the data. If you are new to the CCP, you are invited to join our global research partnership to accelerate the generation of evidence that matters to your patients.
How to join this research partnership ?
If you have comprehensive clinical data on patients with Dengue collected in 2023 or 2024, these can be integrated with those collected by participating countries for an analysis planned in the coming months. See the Dengue CCP CRF for the types of data that are needed. Alternatively, you may collect data prospectively that can be combined for future analyses with other researchers. All participating sites are invited to join the CCP Dengue Committee to support future directions of this effort.
For further information, please see https://isaric.org/research/dengue/dengue-clinical-characterisation-protocol/.
To participate in the initiative, please contact us data@isaric.org
