Acute respiratory infections (ARI) are the leading cause of infectious disease-related morbidity and mortality worldwide, disproportionately affecting low- and middle-income countries and vulnerable populations. Despite their burden, data on ARI, particularly outside epidemic periods, remain fragmented and incomplete.

ISARIC is working to change this. Through an integrated, global network of outpatient and hospital-based sites, we are systematically collecting real-time data on the burden, aetiology, clinical presentation, and outcomes of ARI across diverse settings. This includes both viral and bacterial pathogens, with a focus on seasonal trends, emerging threats, and co-infection patterns.

Our initiative is generating high-resolution clinical, epidemiological, and biological data, linked with scalable pathogen identification strategies and regional biobanking. This approach enables rapid detection of novel threats, strengthens pandemic readiness, and supports the development of locally relevant treatment and prevention strategies.

Beyond surveillance, we aim to enhance patient outcomes by facilitating embedded clinical trials, strengthening health system capacity, and implementing adaptive response mechanisms. By working closely with local researchers, public health stakeholders, and policymakers, we are closing knowledge gaps and ensuring that the evidence generated translates into action before, during, and after epidemics.